How to deal with experimental disallowed space in DoE
Probably not the best title but here goes....If I was wanting to do a DoE screening design followed by optimisation study with a number of factors relating to a chemical reaction, how could I handle temperature, if the setpoint is at the solvent boiling point? Under this circumstance a lower (-1) value is available but studying a higher value (+1) is experimentally challenging. Lowering the setp...