How can you add control runs to a split-plot design?
In pharmaceutical assays we often run controls on the plate which are used purely for the basis of quality control. The controls should not be part of the statistical model used to generate the DoE, and so previously I have tried to generate two DoEs (one for the main experiment, one for the controls) and merge them together. However, this is not trivial when you have a common split-plot setup, as...