Hi @ZHANDOUJI,
As explained by @statman, Stepwise method is not a default model building method recommended with DOE data, as you already have assumed a model that guide your experimentation and data collection strategies. You're not a in a situation where the data collection is imposed to you, and you have to "figure out"/determine a possible likely model for this data.
Starting with your assumed model with the simple Least Squares method should be a good starting point.
You can check the "Fit separately" option.
In order to refine your model (based on p-values, R² and R² adjusted, RMSE, and/or Information criterion like AICc), you can then for each of your response remove the least important/active terms from your model :
You can read more about model building and selection in other related discussions :
Statistical Significance
best model
Analysis of split plot design with full factorial vs RSM
Fit Definitive Screening vs. Stepwise (min. AICC) for model selection
Hope this answer will help you,
Victor GUILLER
L'Oréal Data & Analytics
"It is not unusual for a well-designed experiment to analyze itself" (Box, Hunter and Hunter)