Help to design a complex DoE on Formulation Buffer Screening
I'm planning to optimise a formulation for a liquid drug product. We have a starting material that is in a certain buffer with some excipients and would like to find out, if there is even a better formulation buffer for this drug product regarding stability.
I want to test:
- Different pH ranges (pH 5, 6, 7, but the pH levels are set by different buffer systems (pH 5 = acetate buffer, pH 6 = histi...