DoE when each run is costly and time consuming ( low throughput process optimization in perfusion bioreactors)
Hi, I am looking to perform a DoE to optimized process conditions inside a perfusion bioreactor (with yeast). The throughput on the system I am using is essentially 1 and each run would take 1-2 weeks. Because of these constraints I was thinking about performing one run and varying my factors during the run. I can monitor my responses (product titer and cell specific productivity) by sampling and ...