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Level II

Questions about augmenting a DOE design

Hi, I have a couple of questions about augmenting DOE designs:


1- How can I design more than one block for the extra runs resulting from the Augment Design platform? JMP seems to only give the option to place them in one block. I can only run a specific number on one day or I might have hard-to-change factors.


2-  I'm going to show below an example of my planned DOE for the initial screening run and how I plan to augment it for optimization (RSM). Please let me know if there's a better way to do this or if this looks fine. Note  that my final design will proabably be more complicated (includes mixture), so a DSD will not work.


Acid type (Categorical; L1, L2, L3, L4, L5, L6)

Solvent type (Categorical; L1, L2, L3, L4)

Acid concetration (continuous; -1,1)

Solvent concetration (continuous; -1,1)

Substrate concetration (continuous; -1,1)


After the initial screening (main effects only) run and analysis, I will probably throw out several levels of the acid type and solvent type. I tested this in JMP and it seems that the best way to do this is to delete the rows in the table that correspond to these levels, followed by running the Augment Design platform. Next, I will choose RSM design to get my extra runs. Does this seem reasonable? Thanks.


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