Screening designs - How do we know if the effects are not significant or if the whole data is not good (significant variation) without doing replicates?
To show robustness of a chemical process, we often need to show regulators that selected parameters (temp, equivalents, time and reagent ratios) are not impacting the quality (purity) of final product. In order to show this, regulators prefer performing screening designs. Usually, we want to show that the parameters do not have detrimental effect within the ranges studied, so that the process is...