How to evaluate Alias structures in D-optimal DOE?
My understanding is that D-optimal designs can be good for screening experiments, but you'd better hope there aren't any large interaction effects, otherwise they will bias your main effects, or that you should add some suspected 2-way interactions to your optimal design as a way to avoid aliasing effects. I've been told to avoid Res III fractional factorials, & Plackett-Burman designs for screen...