Hi @jwiltsie,
Here is a section of the JMP help that might be of use:
http://www.jmp.com/support/help/Mixed_and_Random_Effect_Model_Reports_and_Option.shtml
Without seeing your particular results I can't be sure what is happening, but I suspect the model you're fitting has a number of random effects that are likely close to zero/absorbing no variance. When fitting a mixed model, you have the option to allow "unbounded variance components," which means that a variance component can converge to a negative estimate. This might seem strange (or downright ridiculous) since we know in reality a variance can never be negative. But, it's been shown that constraining estimates for the variance components to be positive leads to bias in estimation of the fixed effects (if you're interested in the statistical reasons for this I've included a google scholar search below).
So, what does that have to do with your coefficient of determination for the full model? If many of your variance components are estimated to be negative (meaning they're likely inactive in the population), and whatever fixed effects you're estimating absorb little variance, it's possible for the overall model R2 to be negative.
As I said before, it's hard to know what's happening exactly without seeing more about your particular situation, but hopefully this helps put you on the right path!
- Julian
https://scholar.google.com/scholar?q=unbounded+variance+components+mixed+model&hl=en&as_sdt=0&as_vis...