Hello @ELH,
Yes, you can optimize the total desirability for several responses simultaneously, by clicking on the red triangle next to Prediction Profiler and clicking on "Optimization and Desirability" -> "Maximize Desirability".
By default all your responses will have an importance of 1, so JMP tries to equally optimize the responses, but you can change the importance, goal and ranges for each response by clicking on "Optimization and Desirability" and then "Set Desirability".
More infos in the documentation : Desirability Profiling and Optimization (jmp.com)
For DSDs, you can save your prediction formulas (Prediction Formula + StdErr Pred Formula to have the confidence range) in the datatable, and then re-create the profiler in "Graph" -> "Profiler", specifying your prediction formulas for your 3 responses (Pred + StdErr Pred), and then do the optimization from this recreated profiler. You'll have a complete view on your three responses and they will be considered at the same time for the optimization (compared to single profilers done in the traditional "Fit DSD" platform).
Hope this will help you,
Victor GUILLER
"It is not unusual for a well-designed experiment to analyze itself" (Box, Hunter and Hunter)