Thank you, - Are all of the factors continuous? 3 continuous and 1 Discrete Numeric 3 levels factor - What is the model you are predicting? I want to perform a screening design, main effect, and 2 order interactions For the day to day variations, I do not know if I will have a variation or not. The situation is that I have one hard to change factor that can not change levels easily and I will accept any solution to keep it fixed for a certain level of runs. When I did some preliminary experiment I found that the variation coming from the Whole plot has a negative value and I do not know how to explain this ? bets regrds
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