Sorry, a little late to the discussion and perhaps I don't understand the situation, but it doesn't sound like you are screening (only 3 variables) so DSD would not be what I would use. Here are my thoughts, again it is very difficult to provide great assistance as the complete context is not provided:
1. First, the way I read the situation is you have a factor C that can be set for each chamber (this could be considered nested in chamber?) and Factors A&B that are factorial? But then you also suggest you want the interactions with C?
2. You could think of chambers as "Blocks" or replicates (but treat as a fixed effect). Essentially running the same factorial for each chamber. A, B & C design simple 2^3, so 32 treatments. This gives full resolution for all main effects, 2nd order and 3rd order interactions as well as chamber effect and chamber-by-factor interactions. The chamber-by-factor interactions could be useful as what matching chambers would also mean is the absence of chamber by factor interactions (the effects of the factors are consistent over chambers). You might be most interested in the C-by-Chamber interaction.
3. Or you could try a more sequential approach, Run the 2^3 factorial on one chamber, then perhaps replicate on one other and compare...what did you learn. Then you could modify your design and then decide what to run on the remaining chambers. Or run the 2^2 factorial over all chambers and then experiment on C separately for each chamber.
4. There is no mention of whether you predict non-linear polynomials...so perhaps understand the linear effects before adding quadratic effects?
"All models are wrong, some are useful" G.E.P. Box