Hi @Darshan,
Ok, from what I understand, it seems that F1, F2 and F3 are categorical factors with different levels.
For example,
- F1 is a categorical factor "Carbon", with 3 possible levels to choose from : Sugar / Carbohydrate / Polysaccharide
- F2 is a categorical factor "Nitrogen", with 2 posssible levels to choose from : Protein / Amino-acid
- F3 is a categorical factor "Mineral salts" with 2 posssible levels to choose from : Potassium / Sodium
And besides these factors, you could add continuous factors for the amount of each category like F1_amount, F2_amount, F3_amount and F4_amount (I have added in my example through coded values like -1 and +1, but feel free to use real values for your experiments).
You could then use the Custom Designs platform to set up your factors and define a model according to your requirements/needs, for example with main effects for your factors and 2-factors interactions between your factors.
As an illustration, here is an example with the configuration proposed (and factors for the different categories amounts):
- Defining the factors and model (with main effects and 2-factors interactions):

- Generated design with 42 runs:
This is just an example to show you the method and design creation that could match your requirement of having only one type of C/N/salts used for each experiment, but still analyzing the interactions between specific choices combination. Maybe you won't need the numeric factors linked to the amount of each category levels. There are of course other methods available and the settings of the design could also be made so that the total amount of "sources" is fixed to 100%, or specific combinations are not used thanks to Define Factor Constraints ... If you need more help or guidance, you can explain what are the other requirements in more details.
Please find attached the datatable with the generated design.
Hope this answer will help you,
Victor GUILLER
"It is not unusual for a well-designed experiment to analyze itself" (Box, Hunter and Hunter)