Lots of options and workflows within JMP for this type problem and data. You've told me nothing so far that leads away from doing what I recommend in my second to last paragraph in my initial reply. This will allow you to gain insight with respect to your practical questions BEFORE any modeling work to create response surfaces. At a minimum I suggest exploring these 5 issues:
1. Where's the middle of the responses for each 'x'?
2. What's the shape of the responses for each 'x'?
3. How spread out are the responses for each 'x'?
4. Plot the responses in order of experimental execution.
5. Are there any response data that look suspicious, odd, unexpected, or unusual that might make subsequent modeling more problematic? If so, how will you handle them in subsequent analysis and reporting?
A simple run chart (for issue #4 and the Fit Y by X platform for the rest are your friends here. Graph Builder could work too.
Once you get to modeling, and I presume you have 'useful' models, the JMP Prediction and Contour Profilers will be invaluable for additional response surface visualization and comparison.