Your three variables should be your three columns: ID, Diagnosis, Prognosis.
In the diagnosis and prognosis column you would have your 1/0 or true/false, value for each subject.
ID Diagnosis Prognosis
1 True False
2 Ture True
etc....
Then you can start with fit y-by-x to compare the diagnosis to the prognosis (both columns should be categorical so that you get a mosaic plot and a cross-tabs table). From there look at the JMP documentation on fit y-by-x for agreement statistics. You may also wish to google "FDA guidance on reporting diagnostic tests" for further insight to the types of analyses you might want to run with regard to diagnostic tests.