Is there a way to compare the differences between the LS-means of several groups? In other words, how can I detect differences between the differences in different groups? If I run a linear model on my original data, I can use multiple comparisons to get the difference between the LS-mean of each group and the standard errors of those differences. Can I go a step further and do another test to see, for example, if the difference in the LS-means of groups A and B is different than the difference in the LS-means of group C and D?