*I've changed my recommendation a couple times here. I think the current recommendation is the cleanest approach. Also, previously stated specifying 96 runs, should be 128
Hi @JG,
Welcome to the community! It sounds like you have a specific full factorial design in mind (4x4x3x2x2x2), correct? In each run, each operator should be taking 12 total samples correct? And across all operators, each run should have 48 samples.
If that's all true, I think you actually have 3 levels of blocking: 8 blocks for "run" (48 samples in each run), 32 blocks for Operator (operator is held constant for 12 samples at a time, 4 operator blocks within each "run" block), and 128 blocks for samples from the same cavity (4 blocks of size 3 within each operator block). This would be a split-split plot design with repeated measures. That's pretty complex!
There's a couple ways to approach this. If you want to use Custom Design, you can do that by specifying a split-split plot structure with your 3 2-level factors as "Very Hard" to change, Operator as "Hard" to change, and Cavity as "Easy." Model should probably contain all 2-way interactions. You would then specify 8 whole plots, and 32 subplots, and 128 total runs (you'll need to cross this design with your 3 repeat measures from each cavity to get your 384 total data points). Your design dialog should look something like this:
I was able to get the full factorial for the 128 runs with the default settings, but you can increase the number of random starts or design search time if that doesn't work out for you the first time. You can tell if you got it if the Correlation Map looks like this:
Now, you'll just need to add your 3 repeat measures to your design. You can do this a couple ways. Easiest is probably just add 3 new columns (e.g. Sample 1, Sample 2, Sample 3) and then stack those 3 columns. Your table will then have 384 rows.
I attached my result using this method.
-- Cameron Willden