Using a transformed response or predictor / factor / explanatory variable requires a shift in thinking. All of the analysis is in terms of the transformed variable. Most scientests today, for example, would not transform pH back to hydronium activity.
The nature of the transform might make it easier to back transform the response. For example, if the transform is square root Y, then simply square the prediction. We usually select a value for the Box-Cox transform that corresponds to a physical reality as natural dimensions and relationships often work that way. You can generally think of the value as a power, though it is not exactly the same. So a parameter value of -0.5 would correspond to reciprocal square root.
Once you identify the nature of the transform, you might be able to use a transform in the Fit Model dialog instead of using the Box-Cox transform. JMP will then profile the response in terms of the original response. Otherwise, uou can save the model for the transformed response from Fit Least Squares by clicking the red triangle and selecting Save Columns > Prediction Formula. You can then select the column, select Cols > Formula, and apply the inverse function. After saving the changes to the formula, select Graph > Profiler, select the modified prediction formula, and click OK.