You need to use the Fit Model command available under the Analyze menu. This will allow you to have multiple X variables in your model.
The dialog window for Fit Model will allow you to specify the model structure. Common model structures can be generated using the Macro button. The model type you are describing includes all main terms and two-factor interactions and can be generated using the "factorial to degree" option.
These are the steps:
1. Analyze> Fit Model
2. Select the response column(s) and click the Y button
3. Select the column names of the explanatory variables, click the Macro button and select "factorial to degree"
4. Click the Run button
Hope this helps
Dave
-Dave