Pharmacokinetics centers around the assessment of drug concentrations (absorption, distribution, metabolism, and elimination) in an organism (e.g., humans) and understanding the variability within and between individuals. JMP has supported pharmacokinetic modeling through the Fit Curve platform, which includes options for one- and two-compartment models.
However, a widely used and long-requested method – noncompartmental analysis (NCA) – had been missing. NCA is valued for being model-independent, requiring fewer assumptions than compartmental models. It is commonly used to estimate key pharmacokinetic parameters such as AUC, Tmax, Cmax, and half-life. In this session, we show and discuss a new report in JMP Clinical, called Pharmacokinetics, that allows us to explore and perform NCA on clinical trial data and to use additional data collected for the study to further understand the desired pharmacokinetic parameters.
Presenters
Skill level
- Beginner
- Intermediate
- Advanced
