Hi,
I have carried out range finding to determine high and levles on a set of variables I want to test with a definitive screening design.
I have found for most of them, that that above a certian point there is a reduction in activity in the effect I am trying to measure. So lets say at '1' the variable produces a low response, at '10' a high response, and at '100' back down to a low response.
With a definitive screening design I have the ability to test 3 levels for each factor. I was wondering what the best strategy to find the true maxima of the complete system (12 variables).
So I was thinking my options are:
Set low to '1' and high to '10' (with the axial point being 5) ensuring the variables are in the linear increasing range. However, I am worried that this may miss the true maxima which could arise from interactions with the other variables.
Or
Set low to '1' and high to '100' with the axial point being 10. Therfore, if there were positive interations that may necessetate the higher concentration beyond my original range finding, then would this way be more appropriate?
I would appreciate any thoughts on this!
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