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Try the Materials Informatics Toolkit, which is designed to easily handle SMILES data. This and other helpful add-ins are available in the JMP® Marketplace
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JMP System Requirements (macOS)

JMP 18; JMP Pro, Version 18

OS:

macOS Sequoia (15; JMP release 18.1 and later)*

macOS Sonoma (14)*

macOS Ventura (13)*

macOS Monterey (12)*

macOS Big Sur (11)*

* - Compatible with Intel and Silicon processors

RAM*: 8 GB or more recommended
Drive Space: 1.5 GB
Database: UNICODE compliant ODBC 3.5 or higher (required only if connecting to database); Apple Silicon architecture requires matching ODBC drivers
Other Compatible Software (not required):

R open-source statistical software releases 2.9.1 or higher (Intel architecture of R only)
https://www.r-project.org

MATLAB R2012a (version 7.14.0) or higher

Supported Languages: English, Japanese, Simplified Chinese, Korean, French, German, Italian, Castilian Spanish

JMP 17; JMP Pro, Version 17

OS:

macOS Sonoma (14; JMP Release 17.2 and later)

macOS Ventura (13)

macOS Monterey (12)

macOS Big Sur (11)

macOS Catalina (10.15)

RAM*: 4 GB or more recommended
Drive Space: 1.5 GB
Database: UNICODE compliant ODBC 3.5 or higher (required only if connecting to database); Apple Silicon architecture requires matching ODBC drivers
Other Compatible Software (not required):

SAS 9.4

R open-source statistical software releases 2.9.1 or higher (Intel architecture of R only)
https://www.r-project.org

MATLAB R2012a (version 7.14.0) or higher

A Python distribution from python.org from release 3.7.x or higher. Apple Silicon architecture requires Python with matching architecture

Supported Languages: English, Japanese, Simplified Chinese, Korean, French, German, Italian, Castilian Spanish

JMP 16; JMP Pro, Version 16

OS:

macOS Monterey (12.0, JMP 16.1 and above)

macOS Big Sur (11.1 - Intel or Apple Silicon architectures)

macOS Catalina (10.15)

macOS Mojave (10.14)

RAM*: 4 GB or more recommended
Drive Space: 1.5 GB
Database: UNICODE compliant ODBC 3.5 or higher (required only if connecting to database); Apple Silicon architecture requires matching ODBC drivers
Other Compatible Software (not required):

SAS 9.4

SAS 9.3

R open-source statistical software releases 2.9.1 - 3.3.3

MATLAB R2012a (version 7.14.0) or higher

A Python distribution from python.org from release 3.7.x through 3.9.x. Apple Silicon architecture requires Python with matching architecture

Supported Languages: English, Japanese, Simplified Chinese, Korean, French, German, Italian, Castilian Spanish

JMP Clinical 18

OS:

macOS Sequoia (15; JMP release 18.1 and later)

macOS Sonoma (14)

macOS Ventura (13)

macOS Monterey (12)

macOS Big Sur (11)

RAM*: 8 GB minimum, 16 GB or more recommended
Drive Space: 128 GB minimum, 256 GB or more recommended
Supported Languages: English, Japanese, Simplified Chinese