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Profile -likelihood CIs for risk ratios

Status: Delivered Submitted by on ‎03-13-2022 03:16 AM
4 Comments (4 New)

Proportional Hazards Fit provides profile likelihood based confidence intervals for the Parameter Estimates. Please provide this type of CIs also for the Risk Ratios; this is important because the risk ratios are the usual measure of effect size in survival analysis.

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4 Comments
SamGardner
Staff
Staff
‎07-14-2022 10:19 AM
‎07-14-2022 10:19 AM
Status changed to: Acknowledged

@winfriedkoch0 thank you for this new feature idea.  We are evaluating this idea as a possible future improvement to JMP.

SamGardner
Staff
Staff
‎07-14-2022 10:43 AM
‎07-14-2022 10:43 AM
Status changed to: Investigating
 
SamGardner
Staff
Staff
‎08-31-2022 11:24 AM
‎08-31-2022 11:24 AM
Status changed to: Needs Info

@winfriedkoch0 we have investigated this request, and I wanted to let you know that we do calculate and report Wald confidence intervals for risk ratios (hazard ratios) in Fit Proportional Hazards.  These confidence intervals use normal approximations for the confidence limits.  Does this meet your needs?
( output from example data VA Lung Cancer)

Risk Ratios

Unit Risk Ratios

Per unit change in regressor

 

Term

Risk Ratio

Lower 95%

Upper 95%

Reciprocal

Age

0.991487

0.9739

1.010136

1.0085861

Diag Time

0.999908

0.979971

1.016244

1.000092

KPS

0.967905

0.957488

0.978403

1.0331596

 

Range Risk Ratios

Per change in regressor over entire range

 

Term

Risk Ratio

Lower 95%

Upper 95%

Reciprocal

Age

0.669099

0.288517

1.606371

1.4945466

Diag Time

0.992119

0.175518

3.998028

1.0079435

KPS

0.05484

0.020935

0.143244

18.23482

 

Risk Ratios for Cell Type

 

Level1

/Level2

Risk Ratio

Prob>Chisq

Lower 95%

Upper 95%

Large

Adeno

0.4544481

0.0092*

0.2511038

0.8224612

Small

Adeno

0.7176217

0.2286

0.4181316

1.2316242

Squamous

Adeno

0.3047391

<.0001*

0.1690124

0.5494621

Small

Large

1.579106

0.0862

0.9370433

2.6611104

Squamous

Large

0.6705696

0.1574

0.3853373

1.166935

Adeno

Large

2.2004712

0.0092*

1.2158629

3.9824176

Squamous

Small

0.4246514

0.0019*

0.2476225

0.7282408

Adeno

Small

1.3934918

0.2286

0.811936

2.3915917

Large

Small

0.6332697

0.0862

0.375783

1.0671865

Adeno

Squamous

3.2814957

<.0001*

1.8199618

5.916725

Large

Squamous

1.4912695

0.1574

0.8569458

2.5951289

Small

Squamous

2.3548727

0.0019*

1.3731721

4.0384051

 

Risk Ratios for Treatment

 

Level1

/Level2

Risk Ratio

Prob>Chisq

Lower 95%

Upper 95%

Test

Standard

1.3363418

0.1617

0.8903074

2.0058347

Standard

Test

0.7483115

0.1617

0.4985456

1.1232076

 

Risk Ratios for Prior

 

Level1

/Level2

Risk Ratio

Prob>Chisq

Lower 95%

Upper 95%

Yes

No

1.0750063

0.7554

0.6820551

1.6943478

No

Yes

0.9302271

0.7554

0.5901976

1.4661572

 

SamGardner
Staff
Staff
‎09-02-2022 03:51 PM
‎09-02-2022 03:51 PM
Status changed to: Delivered

Based on additional communication, the Wald confidence intervals are sufficient to meet this need.  Thank you for your suggestion and continued engagement with JMP!