JMP® 19.0.4 and higher does not find R when initialized. The following JMP alert is returned.

The problem is that JMP 19.0.4 is assuming the R install path is C:/Program Files/R/R-4.5.0, despite the actual R install path being C:/Program Files/R/R-4.5.
Workaround:
Define R_Home as C:/Program Files/R/R-4.5.x before launching JMP 19.0.4 or higher.