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Summer DOE Series: Mixture DOE

Paint, salad dressing, soap. What do they have in common? They are all mixtures. To optimize a mixture, you must change the proportions of the ingredients or components while keeping the total mass or volume the same. If this sounds like a system you are working with, watch this video to learn how to create and analyze mixture DOEs.


Q&A / Discussion

Big thanks to @Victor_G for help with the Q&A!


Q: What modeling techniques can we use for mixture DOE?

A: In a model-specified mixture design, linear regression models will test the specified model effects and make acceptable models. In model-agnostic mixture designs, machine-learning modeling methods (neural networks, SVM, Gaussian process) may also be quite helpful.


Q: How did you create the cost column?
A: The cost column is a simple column formula that sums up the cost for each component (saved as a table variable) multiplied by the proportion of that component in the mixture.


Q: How can we set a screening mixture design in Custom Design?

A: Create a custom design and add the mixture factors and the range for each factor in the formulation. For a screening design, you may only be interested in main effects, which is the default setting for this. If you want to look for non-linear blending terms, you will need to add interactions to the model.


Q: How we can plot four or five component mixtures/formulations?

A: When you add more than three variables to the ternary plot, you will get a scatter plot of ternary plots. These plots will be arranged so that two axes are two different variables; the third axis is the sum of all the other components.


Q: Can you use a definitive screening design for mixtures? 

A: If you have true mixture factors, then you cannot use a DSD. However, if your formulation components are truly independent, you can use a DSD.

Last Modified: Sep 7, 2023 9:44 AM