script for creating a table of p values

[#1]

I have a large table of 40 rows (4 groups of 10 samples) and 10000 columns of values—

1. Is there a way for me to quickly run t-tests/ANOVA comparing particular group against another group, for each of those columns and list the p-values in a table to quickly sort through to understand the ones that are significantly different? 

2. Also, is it possible to set the p-value is such test to correct for multiple correction?

Thanks

[#2]

How do we know if the significantly different values are increased/decreases and how do we know the baseline group?

[#3]

The Oneway Platform allows for the display of the group means.  The sample script does not capture that data, but it could have that information included.

Concerning the identification of the Baseline Group.  the assumption is that either the data would contain appropriate labeling, or that the analyzer of the data would know that information.