While I haven't looked at the links provided by @Victor_G , and I agree with everything others have contributed to date, my first step, always, never fail, before any statistical test p, t, F, or otherwise, is to plot response vs. factor scatter plots. I hope at least one of those references encourages this approach. Your eye and process knowledge are the most sensitive 'detectors' of effects I've ever encountered. In 30 years of practice of DOE in an industrial setting I honestly can't recall one experiment we analyzed where a LOF test for curvature was 'significant' that didn't show up in scatter plots first.