Hi @SimonFuchs,
You can have more information about the optimization done by the profiler here : Desirability Profiling and Optimization (jmp.com)
To answer your first question, you'll find on this page the answer : "The overall desirability for all responses is defined as the geometric mean of the desirability functions for the individual responses."
So as you guess, if you have several responses to optimize, the Profiler will try to find the best compromise that reach an overall best desirability score (weighted geometric mean of individual desirability score for each responses). You can specify different weight for the responses (called "importance", CTRL+click on desirability curve of the response to specify goal, high/medium/low values and importance) if you want to emphasize the optimization on some responses compared to others. The importance, slope/curve of the desirability functions and objective (maximize/minimize/reach target/none) have all an influence on the optimum found.
The true global optimum is not always possible to find, as there may be no exact solution to the problem you try to optimize (or multiple solutions may be possible). This is why you may have sometimes slightly different answers, depending on the optimization process: convergence tolerance, number of iterations, method used (depending on the problem: Construction of Desirability Functions (jmp.com)) : Maximization Options Window (jmp.com) but also depending on your responses' characteristics, like uncertainty (the optimum found will only be an approximation of the true unknown optimum), desirability profiles (a steep slope in the desirability profile may have a less variation in the differences from several optimums found than a slower slope (=less constraint in the optimization)), and values of your factors (but JMP uses several random starts for the optimization process, so this shouldn't be a big problem and the probability to get stuck in a local optimum should be limited).
I hope this complementary response will help you,
Victor GUILLER
L'Oréal Data & Analytics
"It is not unusual for a well-designed experiment to analyze itself" (Box, Hunter and Hunter)