By modeling method, yes, Standard Least Squares, Stepwise, or even the non linear methods such as Partition, and if you have JMP Pro, Bootstrap Forest, or the any of the penalized regression methods in the Generalized Regression platform. Each of these pathways will have as part of the workflow the option to go from model selection to evaluation to prediction using the Profiler right in the same workflow.
When you say 'linear interpolation' I'm not 100% sure what you are getting at, but, what the profiler does conceptually is treat your n dimensional factor space as an n dimensional surface and allows for the optimizing algorithm to stop at any point in the factor space which meets the maximum desirability for the response you've specified within the Profiler set up. You can also include surface plots to visualize the response surface around the optimal factor settings. There is also a built in simulation capability. Lots of options within the Profiler for exploration and visualization.
I was a JMP user since version 1...and I think it's safe to say...at least for many, JMP's Prediction Profiler capabilities to this day are one of, if not the, defining 'killer app' in the entire JMP ecosystem.