Try the Materials Informatics Toolkit, which is designed to easily handle SMILES data. This and other helpful add-ins are available in the JMP® Marketplace
I would like to ask what formula I can put in Column 3 to get this kind of data? Means if any row of Column 2 data includes data of Column 1, then the row will print out "Y" at column 3. If there's no related value in Column 2, then the row will print out "N"