In addition to Phil's questions, could you please provide the data in a JMP file? Here are a couple of ideas:
1. You can assess the consistency of the instrument-to-instrument variation using range charts (this would require stacking the instrument column). This will show there are some instances where there is significantly more variation instrument-to-instrument for some samples. It is virtually impossible to evaluate the data set without subject matter knowledge regarding practical significance.
2. You can "normalize" the data for each sample by creating a column that takes the difference of the measured values from the target value for each sample.
3. I have attached a couple of data tables from your table. First to look at the data (graph builder and variability plots) Then to look for stability (control charts (Range chart). Then I summarized the data (which you could argue may not be appropriate due to the inconsistency) and did multivariate analysis of the means and standard deviations (note outliers and strong correlation, as the sample increases so does the variability instrument-to-instrument).
After looking at the data, you can decide if you want any other tests to determine if these are "statistically" significantly different.
"All models are wrong, some are useful" G.E.P. Box