Dear Colleague

My lab has discovered a biomarker that predicts bad outcomes for pregnant moms. I am trying to figure out how to determine an optimal cutoff in the multivariable model, i.e., one that includes all the clinical characteristics and the biomarker that predicts the binary outcomes, i.e., bad outcomes for pregnant moms. I use the decision threshold tool to change the sensitivity and specificity, but I have difficulty translating model probability to actual biomarker levels. Any help would be most appreciated. I am a dumb clinician, so if you walk me through the process, that would be even more helpful.

Thanks much