Hi @JaNeu ,
If you really made the DOE with the disallowed combination expression (using JSL, as X1>X2), then the profiler and prediction formula should automatically be undefined for cases where X1>X2. See for example the simulated DOE in the attached data table and associated scripts.
Or, if you already have a prediction formula and need to add the constraints later, you can go Graph > Profiler and select your prediction formula. Then, you can add the linear restraints later.
Hope this helps,
DS