I don't understand your question, but here are my thoughts:
1. the levels in a definitive screening design are coded -1, 0, 1. These do not represent actual levels, so you can use whatever actual levels you want. I don't know what you mean by "setpoint level"?
2. Regarding your factor that currently runs at -0.5 and can't be tested <-0.5, you can use the -0.5 as the -1 setting and choose 2 other levels equally spaced for the 0 and 1 coding. The three levels in a definitive screening design are so the quadratic effect can be estimated.
"All models are wrong, some are useful" G.E.P. Box