To add just a bit to everything @Victor_G wrote, which I agree with, is have you plotted your responses vs. predictors in a simple scatterplot fashion? I'd start there, even before modeling. This gives you a fighting chance at proposing an initial model that will most appropriately fit the data. It will help you identify a general pattern in the responses (linear, curvilinear, etc.) outliers, odd looking data points, and, if you have replicates of the predictor's values, a chance to look at their variability in a graphical fashion. As I always told my engineers, scientists and others, the three steps to successful data analysis are. 1. plot the data. 2. Plot The Data. 3. PLOT THE DATA!