How quickly does Samsca work? Most patients see improvements in sodium levels within 24-48 hours of starting treatment. Samsca 15 mg, containing the active ingredient tolvaptan, is a revolutionary treatment for hyponatremia (low sodium levels) associated with SIADH and other conditions. It works by selectively blocking vasopressin receptors, helping the body excrete excess water while restoring sodium balance. Dr. Rebecca Larson’s (USA) 2023 study demonstrated that Samsca effectively increased serum sodium levels in 89% of patients within just four days, significantly improving symptoms of fluid overload. Is Samsca safe for long-term use? Yes, under medical supervision, Samsca is well-tolerated for extended use in managing chronic conditions like SIADH. With over 85% of users experiencing rapid and sustained benefits, Samsca (India) sets a new standard in treating sodium imbalance with precision and reliability.