Using Multiple Time Point Dissolution Specifications with Models

[Charlie]

I have a stacked table with a Time Point (X) column, a Cumulative Release (Y) column, and several columns of factors from a DOE. We have different specification limits for release at various time points in the dissolution curve, as required by the FDA. In development, I need to fit curves to the data, use models to determine significant factors, and optimize factors using Desirability Functions. I can fit curves with this table, but I cannot use the Desirability Functions because each column can only have one set of specifications saved with it. I can split the table by Time Point and make a new table, but that creates more documentation and review work, as required by our data integrity rules. It would be nice if there was a way to account for these specifications in Fit Model and FDE.

Suggestions

• Allow specification limits to be set conditionally. This may help resolve the problem for non-FDE models.

• In FDE, allow more than one target curve. Curves based on upper spec, target, and lower spec would allow explorations of the variable space for each target curve.

I use JMP Pro 16.2.0

[Sarah-Sylvestre]

@Charlie - Thank you for your suggestion! We have captured your request and will take it under consideration.

[Valerie_Nedbal]

@Charlie i would have a workaround for this problem

Do a DOE for each run, one particular batch, different columns would be the dissolution at different time point with specifications, the data set should look like that: 

Do a model using the fit model an use maximize desirability function

In such you will find the best combination of your factors that will set your dissolution curve on target. Would that help?