This is part of a series to illustrate the potential role of JMP in the understanding and teaching of key concepts in Chemistry with a current focus on Polymer science. Microstructure calculations allow a researcher to investigate the detailed composition of a polymer either prior to its synthesis or after discovering a unique performance characteristic. Additionally, JMP can be utilized, via the Non-Linear platform, to optimize calculated structural parameters from experimental data. The Polymer Microstructure systems take advantage of the matrix algebra within JMP to simulate a Bernoullian process based on construction of a stochastic matrix.