Determining Confidence Limits for Linear Combinations of Variance Components in Mixed Models
Apr 9, 2020 6:21 AM
| Last Modified: Apr 9, 2020 6:54 AM
Random Estimates Combination Confidence Limit Calculator.jmpaddin
Generating linear models that include random components is essential across many industries, but particularly in the Pharmaceutical and Life Science domains. The Mixed Model platform in JMP Pro allows such models to be defined and evaluated, yielding the contributions to the total variance of the individual model components, as well as their respective confidence intervals. Calculating linear combinations of these variance components is straightforward, but the practicalities of the problem (unequal Degrees of Freedom, non-normal distributions, etc.) prevent the corresponding confidence intervals of these linear combinations from being determined as easily. Previously, JMP Pro users have needed to turn to other analytic software solutions, such as the “Variance Component Analysis” package in R, to resolve this gap in functionality and fulfill this requirement. This add-in, available for use with JMP Pro, uses parametric bootstrapping to obtain the needed confidence limits. Instructions for use can be found in the poster presented at JMP Discovery Munich 2020: Determining Confidence Limits for Linear Combinations of Variance Components in Mixed Models (2020-E...