I'm a bit confused by your query? If you are just fitting y by x, you can get multiple models by fitting line, polynomial, etc. (select the red triangle to get multiple options). Prediction Profiler is usually associated with fit model where there are multiple X's and the profiler contains the estimates from the model entered into the software. TMK, the profiler is the same in 15.1 as other versions.
Perhaps start here:
https://www.jmp.com/support/help/en/16.0/#page/jmp/profiler-features-in-jmp.shtml#
"All models are wrong, some are useful" G.E.P. Box
