Hi Simon,
Classic statistician answer: it depends! There is not a general answer to this. It depends how much you need to change the design.
If it is just changing factor ranges, then it would be relatively simple. Changing the values in the design, assuming you stick to low, centre, and high values, will not affect the properties of the design. (Recode would help here)
If you need to add more factors, it will be more complicated. You will most likely need to take the table with the existing factors and use these as covariate factors (candidate runs) in Custom Design with your additional factors added. This will not result in a Definitive Screening Design.
I hope this helps,
Phil