Gigi,
A quick, basic question. Are you creating this using Custom Design or are you choosing the Screening Design platform?
If you are using Custom Design, you are creating a D-Optimal design, not a factorial-type design (although they may end up looking the same). In this scenario there may not be any pure confounding. As such, you cannot modify which effects are confounded because the D-Optimal routine does not work that way.
If you are using the Screening Design platform, then you have some options.
After specifying the 5 factors and the blocking variable (I am assuming you choose the 16 run design with 4 blocks, but the reports will look the same, regardless) you open up the Aliasing of Effects report. You will see which interactions are confounded with blocks.
If you wish to change the confounding pattern then you go into the Change Generating Rules and check the boxes appropriately to get the confounding pattern that you want to see. CAUTION!!!! You really need to know what you are doing to change the generating rules. If you are not careful you can end up with a really lousy design, even resolution 2. So please be careful if you go this route!
Dan Obermiller