Hi @keita_ ,
There are a few thoughts on this:
1. The authors have created the 'whole parameter' model and further refined it (i.e. with stepwise regression to reduce model terms) and then performed Design Space analysis - this would make more sense as you want to refine your model and reduce your non statistically significant terms before you attempt to perform Design Space profiling: if the model is overfitting then the profiles will be misleading.
2. Has the author mentioned any blocking considerations in the model? Have they discussed if they combined their Placket and central composite results together for the model creation?
3. The other (more unfortunate but common) likelihood is the results aren't reproducible, unfortunately this can happen in publications which is often why authors are reluctant to share their full data!
Hope this helps,
Many thanks,
Ben
“All models are wrong, but some are useful”