Data from a clinical trial should be examined by as many eyes as possible. Each individual brings a unique skill set important for understanding patient safety, protocol adherence or data insufficiencies that can affect the final analysis. Clinical data review is extremely time-consuming; a major reason for this prolonged effort involves the data collection process. To perform the final analysis as early as possible after the trial ends, data are collected and cleaned as they become available. Database software can track changes over time, but these tools are limited to few individuals and rarely available for the submission-ready data sets required for analysis. New features available in JMP Clinical 4.1 accelerate clinical trial reviews.