Karen G. Lloyd uses molecular biological techniques and geochemistry to study the diversity and functions of microbial life in the deep- sea, mud volcanoes, subseafloor sediments, methane seeps, terrestrial volcanoes, hot springs, serpentinizing springs, Arctic fjords, and ancient permafrost. 

Much of her work focuses on exploring how individual microbial cells may live for thousands of years in these deep subsurface realms.

Formerly a Professor at the University of Tennessee, Lloyd is currently the Wrigley Professor of Earth Science at the University of Southern California.