Hi @AgnieszkaL,
I was able to replicate a similar design for the five factors and including Day and Analyst. It won't be exactly the same as the example due to randomization.
I'm not sure how they included the information about the independent replicates for each nominal potency. Do you know whether this was also via DoE or was it something else?
Anyway, I believe this was an initial 8-run custom design that was augmented with 8 additional center points. First, I created the design via the custom design with the following factors:
![Owen_Jonathan_0-1711558920808.png Owen_Jonathan_0-1711558920808.png](https://community.jmp.com/t5/image/serverpage/image-id/62734i05E7D6155D6F669B/image-size/medium?v=v2&px=400)
The table below is what you get. Since Day was a blocking factor, we wouldn't be able to augment the design with center points. I had to change the design role for Day by clicking the asterisk and changing it into a categorical factor:
![Owen_Jonathan_1-1711559031321.png Owen_Jonathan_1-1711559031321.png](https://community.jmp.com/t5/image/serverpage/image-id/62735iDCB976D2591AAF51/image-size/medium?v=v2&px=400)
After this, go to DoE > Augment Design > Fill in the Y and all the factors as the X. Then, Add Centerpoints > 8 and click Make Table to get the following data:
![Owen_Jonathan_2-1711559168031.png Owen_Jonathan_2-1711559168031.png](https://community.jmp.com/t5/image/serverpage/image-id/62736iFB369FBCA636A382/image-size/medium?v=v2&px=400)
You can then change the -1 to Low, 0 to Mid and +1 to High.
Let me know if this helps!