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TOST analysis help

I am trying to do TOST analysis for different CQAs. I want to create forest plots, where I can have all items in one plot rather then individual one for all CQAs. I have attached examples of both combined one (from research paper) and the individual one I created in JMP. Please, see if anyone can help with this.

 

Thanks!

1 REPLY 1
MRB3855
Super User

Re: TOST analysis help

Hi @AutoIconsIguana : The way you can do it is as follows:

1. Your data should have three columns: Y, Group, and CQA

2. Fit Y by X platform: Response = Y, Factor = Group, By = CQA

3. Get your 90% confidence intervals as you have; but first, hold down the control key when choosing that option so the intervals are calculated for each CQA.

4. Right mouse click on the confidence interval output for one of the CQAs and choose "Make Combined Data Table".

 

5. The data set from 4 above can be used with Graph builder to get the plot you want.

6. Drag (together) the lower and upper bound to to the X axis.

7. Choose Bar graph from the Bar icon at the top of the Graph Builder GUI.

8. Then in the Bar Style dialog (under Bar on left hand side) choose "Interval".

9. Then drag the mean difference to the X axis as well.

10. Then drag CQA to the "Group" section (right Y axis).

11. Then add reference lines to the X axis based on your equivalence limits.

 

You can also to this via similar steps if you have a separate Y column for each CQA. The difference is you'll put all the Ys in the "Response" section, and the "By" section will be empty. Then carry on as above from 3-11.

 

Then embellish as desired. 

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