Risk adjustment for comorbidities for analysis of survival ?
Apr 13, 2020 11:05 AM(349 views)
I compared and analyzed two different patient populations (Virus infection Type 1 and Virus infection Type 2) with one specific treatment in regards to outcome.
Kaplan Meier among those groups did not show any difference - which is good - so can make the statement that the unadjusted survival among both groups is the same.
However, it seems like one group (eg Virus infection Type 1) is being "sicker" by going into the disease process, by either being older (as a continuous variable) or having more , or other comorbidities than the population Virus infection Type 2. I identified those differences in the pre-existing population by univariate analysis (logistic regression and chi-square depending on).
I want to adjust a priori before I do Kaplan Meier analysis to see if this population (Virus Type infection 1) if I adjusted for those risk factors this patient has actually a relative survival benefit ? Or in other words - I want to risk adjust for eg advanced age, and come to the conclusion - as has been shown that the survival is the same ?!
Thanks a lot, very timely and important analysis. Marc