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Jan 23, 2017 1:51 AM
(1243 views)

Hi,

More of a general statistics question than JMP per se but I thought worthwhile to get some opinions.

I'm looking at doing some MDL (Method Detection Limit) by spiking samples at different levels. The data from the line allows me to make a regression and I use the data from the line to calculate my MDL and the linearity of my data. It is not possible to do more than12 points (though I would love to)

Up till now, I have been doing 4 levels in triplicate - 12 points (say 0, 5, 10, 15). However it not more beneficial to do 6 levels in duplicate? I would think that you get more data on the regression and you can still get standard deviation with respect to the line.

Thanks

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Jan 23, 2017 5:28 AM
(1234 views)

You could use JMP Custom Desgn for this problem. You have a single response and a single continuous factor. Enter the regression model for the curve. If the curve is linear then the default model suffices. If there is some curvature, then add a second order power. Enter 12 for the user defined number of runs. The replication that results is helpful but more concentrations will not. You only need two or three concentrations. This design is more informative than the original design (four levels) or the proposed alternative design (six levels).

Learn it once, use it forever!

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Jan 25, 2017 4:09 AM
(1187 views)