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You can select all the response columns and then select Cols > Standardize Attributes. Add the Response Limits column property in the bottom half of the dialog. Just change the goal to Minimize and leave the limits blank.
The desirability function is used to define the goal for the response, not the factors. Factor settings that maximize desirability is found using the current model.
Do you mean that you want to set all factors to their minimum value, independent of the desirability?
You can select all the response columns and then select Cols > Standardize Attributes. Add the Response Limits column property in the bottom half of the dialog. Just change the goal to Minimize and leave the limits blank.